The Role of FoxC2 Transcription Factor in Tumor Angiogenesis
Identifieur interne : 004A81 ( Main/Exploration ); précédent : 004A80; suivant : 004A82The Role of FoxC2 Transcription Factor in Tumor Angiogenesis
Auteurs : Tsutomu KumeSource :
- Journal of Oncology [ 1687-8450 ] ; 2011.
Abstract
Much has been learned about the mechanisms underlying tumor angiogenesis, and therapies that target vascular endothelial growth factor (VEGF) to limit tumor angiogenesis and subsequent disease progression have recently been approved. However, the transcriptional mechanisms that regulate pathological angiogenesis remain largely unknown. FoxC2, a member of the Forkhead box (Fox) transcription factor family, is critical for vascular formation during development, and recent studies have shown that FoxC2 is expressed in the endothelium of tumors in both humans and mice. In a B16 mouse melanoma model, Foxc2 deficiency reduced tumor growth and neovascularization and was associated with impairments in mural-cell coverage and increases in endothelial-cell apoptosis in tumor blood vessels. FoxC2 is also expressed by tumor cells in human breast, colonic, and esophageal cancer and participates in the epithelial-mesenchymal transition (EMT), a key process that leads to the invasion and metastasis of aggressive tumors. Collectively, these observations suggest that FoxC2 is essential for tumor angiogenesis and disease progression and that FoxC2 may be a viable target for cancer therapy.
Url:
DOI: 10.1155/2012/204593
PubMed: 22174714
PubMed Central: 3228356
Affiliations:
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However, the transcriptional mechanisms that regulate pathological angiogenesis remain largely unknown. FoxC2, a member of the Forkhead box (Fox) transcription factor family, is critical for vascular formation during development, and recent studies have shown that FoxC2 is expressed in the endothelium of tumors in both humans and mice. In a B16 mouse melanoma model, Foxc2 deficiency reduced tumor growth and neovascularization and was associated with impairments in mural-cell coverage and increases in endothelial-cell apoptosis in tumor blood vessels. FoxC2 is also expressed by tumor cells in human breast, colonic, and esophageal cancer and participates in the epithelial-mesenchymal transition (EMT), a key process that leads to the invasion and metastasis of aggressive tumors. Collectively, these observations suggest that FoxC2 is essential for tumor angiogenesis and disease progression and that FoxC2 may be a viable target for cancer therapy.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Hanahan, D" uniqKey="Hanahan D">D Hanahan</name></author><author><name sortKey="Weinberg, Ra" uniqKey="Weinberg R">RA Weinberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Carmeliet, P" uniqKey="Carmeliet P">P Carmeliet</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ferrara, N" uniqKey="Ferrara N">N Ferrara</name></author><author><name sortKey="Kerbel, Rs" uniqKey="Kerbel R">RS Kerbel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcdonald, Dm" uniqKey="Mcdonald D">DM McDonald</name></author><author><name sortKey="Choyke, Pl" uniqKey="Choyke P">PL 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Gartel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bhat, Ug" uniqKey="Bhat U">UG Bhat</name></author><author><name sortKey="Halasi, M" uniqKey="Halasi M">M Halasi</name></author><author><name sortKey="Gartel, Al" uniqKey="Gartel A">AL Gartel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name></author><author><name sortKey="Hong, X" uniqKey="Hong X">X Hong</name></author><author><name sortKey="Hussain, M" uniqKey="Hussain M">M Hussain</name></author><author><name sortKey="Sarkar, Sh" uniqKey="Sarkar S">SH Sarkar</name></author><author><name sortKey="Li, R" uniqKey="Li R">R Li</name></author><author><name sortKey="Sarkar, Fh" uniqKey="Sarkar F">FH Sarkar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name></author><author><name sortKey="Hussain, M" uniqKey="Hussain M">M Hussain</name></author><author><name sortKey="Sarkar, Sh" uniqKey="Sarkar S">SH Sarkar</name></author><author><name sortKey="Eliason, J" uniqKey="Eliason J">J Eliason</name></author><author><name sortKey="Li, R" uniqKey="Li R">R Li</name></author><author><name sortKey="Sarkar, Fh" uniqKey="Sarkar F">FH Sarkar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Radhakrishnan, Sk" uniqKey="Radhakrishnan S">SK Radhakrishnan</name></author><author><name sortKey="Bhat, Ug" uniqKey="Bhat U">UG Bhat</name></author><author><name sortKey="Hughes, De" uniqKey="Hughes D">DE Hughes</name></author><author><name sortKey="Wang, Ic" uniqKey="Wang I">IC Wang</name></author><author><name sortKey="Costa, Rh" uniqKey="Costa R">RH Costa</name></author><author><name sortKey="Gartel, Al" uniqKey="Gartel A">AL Gartel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gusarova, Ga" uniqKey="Gusarova G">GA Gusarova</name></author><author><name sortKey="Wang, Ic" uniqKey="Wang I">IC Wang</name></author><author><name sortKey="Major, Ml" uniqKey="Major M">ML Major</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Kume, Tsutomu" sort="Kume, Tsutomu" uniqKey="Kume T" first="Tsutomu" last="Kume">Tsutomu Kume</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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